This NIH Collaboratory Rethinking Clinical Trials Grand Rounds features: Jerry H. Gurwitz, MD, Chief, Division of Geriatric Medicine, University of Massachusetts Medical School and UMass Memorial Medical Center, Executive Director, Meyers Health Care Institute, A joint endeavor of University of Massachusetts Medical School, Fallon Health and Reliant Medical Group; and Richard Platt, M.D., M.Sc., President, Harvard Pilgrim Health Care Institute.