Carolinas Collaborative

North and South Carolina are home to 4 CTSA hubs: Duke University, the Medical University of South Carolina, the University of North Carolina at Chapel Hill, and Wake Forest University. The four CTSAs have partnered with Health Sciences South Carolina (HSSC) to create the Carolinas Collaborative, a data resource that harmonizes the electronic health record data across the institutions to expedite clinical research and quality improvement activities.

In an effort to promote inter-institutional collaborations and to increase utilization of the Carolinas Collaborative available resources, the four CTSAs are soliciting applications for proposals that involve at least two of the Carolina CTSAs and utilize the data available from the Carolinas Collaborative to generate new knowledge and improve the quality of care delivered to patients in the Carolinas. This collaborative pilot Request for Application (RFA) is in line with the priorities of the NIH and other funders to use the electronic health records for clinical research within and across integrated delivery systems.

The work should collect preliminary data to lead to a competitive proposal to an external funding agency (NIH, AHRQ, PCORI, etc.) within 1 year from funding.

An informational webinar will be held on Friday, June 29, 2018 from 10-11am:


View the Carolinas Collaborative RFA (pdf)

View slides from the informational webinar (pdf)

New requirements for funded pilot grants

The NC TraCS Institute is funded through a CTSA grant from NIH's National Center for Advancing Translational Sciences (NCATS). NCATS recently instituted a new policy requiring the review and approval of all TraCS pilot grants involving human subjects research prior to TraCS funds being released. Therefore, if your proposal is funded and involves human subjects research, TraCS will require additional documentation to send to NCATS. NCATS expects to complete their review in less than 30 days. The NCATS review can occur concurrently with the IRB review; however, final NCATS approval is contingent upon IRB approval.

Submission Due Date

August 15, 2018

Note: Submissions should be received by 5:00 pm on the submission due dates.

Apply Online

More Information

Learn more about current Carolinas Collaborative research projects

Pilot Program Frequently Asked Questions