CER Study Examples

Examples of CER Studies Using Secondary Databases

Studies Comparing Treatment Choices

  • Cancer incidence among those initiating insulin therapy with glargine versus human NPH insulin.
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  • Effect of adjuvant chemotherapy on survival of patients with stage III colon cancer diagnosed after age 75 years.
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  • Acute kidney injury in statin initiators.
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  • Health outcomes for vaginal compared with cesarean delivery of appropriately grown preterm neonates.
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  • Comparative effectiveness of multivessel coronary bypass surgery and multivessel percuatenous coronary intervention: a cohort study.
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Studies Comparing Diagnostic Tests

  • Evaluating comparative effectiveness with observational data: endoscopic ultrasound and survival in pancreatic cancer.
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Studies Comparing Providers

  • Comparison of pediatric surgical outcomes by surgeon’s degree of specialization in children.
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  • The comparative effectiveness of surgeons over interventionalists in endovascular repairs of abdominal aortic aneurysm.
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Pragmatic Trials / Large Simple Trials

Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life routine practice where results may be more generalizable and applicable to clinical care. Unlike explanatory trials which aim to evaluate the efficacy of an intervention in a well-defined, homogenous population and controlled setting, pragmatic trials aim to examine the effectiveness of interventions in routine patients and routine practice.

Examples

  • Full coverage for preventive medications after myocardial infarction.
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  • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
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  • PROspective Multicenter Imaging Study for Evaluation of Chest Pain – The PROMISE Trial.
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  • Effect of Glucose Monitoring on Patient and Provider Outcomes in Non-Insulin Treated Diabetes.
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Databases

View a list of databases available at UNC and RTI