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Overview
The objective of the KL2 Program is to train and develop junior investigators who will become the next generation of successful translational researchers.
Historically, scientists have been trained to conduct research within their own individual disciplines. Such a single-discipline approach to complex biomedical
and health-related problems is unlikely to generate comprehensive solutions or to move discoveries from the basic science laboratory to clinical trials and into
the practice setting. More recently, the NIH has recognized the need for a paradigm shift in which investigators from many fields join one another in
multidisciplinary teams. Specifically, scholars will become “new clinical research leaders who can cross the boundaries of their disciplines and
draw upon the strengths of other fields.” View the NIH road map.
The KL2 Program is designed to support the early career development of clinical researchers who will be expected to achieve excellence in
their ability to design and oversee research in multidisciplinary team settings and to become leaders in various fields of clinical research,
particularly those that are critical to the overall mission of the National Institutes of Health (NIH). Through a curriculum that includes
didactic and experiential learning, scholars will gain:
- An appreciation of diverse clinical research disciplines;
- An understanding of methodological and analytical concepts necessary to design rigorous clinical research;
- An opportunity to apply their knowledge through a mentored and independent research experience that leads to future grant proposals; and
- Access to support from the Shared Biostatistical Research Core for the KL2 Program.
For specific information on eligibility, the application, and the review process please see the FAQ section.
Leadership
Education and Training
The KL2 Program provides access to several courses which form the core of our translational
research curriculum and may be taken either for credit as part of a formal degree granting program or audited
depending on the scholar’s needs. A plan for didactic training is requested of each applicant to the KL2 Program outlining participation in the Core curriculum or the reasons for a request for exemption. Applicants may also propose an alternative didactic training plan that includes other courses relevant to their research.
Core curriculum (required courses):
| EPID 805/806: |
Clinical Epidemiology Research Methods and Clinical Research Skills
Fall and Spring, Monday and Friday 2-4 pm
An intensive course in proposal development. In addition, the course covers project management and implementation and additional clinical research skills. Participants in this sequence should be ready to write a 10-25 page proposal for a career developmental award (K award or foundation), an NIH research grant (R01, R03, R21, etc.), or a foundation research grant. Substantial mentor involvement in the development of the project proposal is required. We encourage participants to take this course sequence in their second year whenever possible, as we have found that the first-year methods courses add substantially to the readiness for participation in this class. Under some circumstances, participation in this course sequence during the first year of participation in the K30 is acceptable. The course sequence is limited to a maximum of 24 participants. All participants are required to remain in the course for the full year and to participate fully in all aspects of the course. |
| EPID 896: |
Clinical Research Curriculum Seminar
Two-year, four-semester seminar. Meets weekly: Friday 12-2 pm
Each seminar introduces the trainees to scholarly exchange of ideas, the value and process of peer review, and examples of applied clinical research concepts across the entire spectrum of disciplines and types of investigations. The dedicated faculty provides continuity. In addition to hearing speakers of national prominence, the primary activities include:
- CRC Small Groups: The small groups comprise junior investigators with clinical research interests (e.g. translational research, clinical epidemiology/clinical trials, health services). The small groups meet once a month to have scholars review challenges to research projects, present and receive peer review of scholarly products, and prepare for work in progress presentations to the large group. The small groups are multidisciplinary. For example, the 2004-5 clinical epidemiology/clinical trials small group includes physicians, pharmacists, a clinical psychologist, and a physical therapist.
- CRC Work-In-Progress and Mock Study Sessions: Alternating with small group sessions, the Work-in-Progress sessions provide an opportunity for the CR scholars to present and discuss their research progress, to practice oral presentations for national meetings, and to take part in the mock study section reviews of their grants or proposals that are nearing completion. Scholars will be expected to present their ongoing research projects in a manner that is understood by a broad audience. Mentors are invited to attend presentations.
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| EPID 711: |
Clinical Measurement and Evaluation
Fall (Miller)
This course provides a lecture and problem-based introduction to the fundamental concepts of epidemiology, including clinical epidemiology theory. The emphasis is on clinical research issues involving study design, measurement, and analysis. |
| BIOS 541/542: |
Quantitative Methods for Health Care Professionals
Fall and Spring (Garrett)
This two-semester sequence provides scholars with basics of statistical inference, practical experience in analyzing clinical and health care research data sets, ability to appraise critically the design and analysis of studies in the medical and health care literature, and an understanding of the overlap between standard statistical and epidemiology methods. These courses are structured to provide scholars with practical, hands-on opportunities to demonstrate their competencies, including commonly used statistical packages. |
| KL2 Seminar: |
Alternate Fridays from 1-2 pm
This seminar is required of all scholars in the KL2 program and includes routine progress reports, rehearsals for national talks, and other topics. |
Mentored and Independent Research Projects
Information on Shared Biostatistical Research Facility
Current and past scholars
Apply
The application cycle for this year has closed.
Contact Info
Susan Pusek, MPH, MS
919-966-0128
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